49 US AI Startups Securing Over $100M Funding in 2025
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2024’s AI Funding Landscape: A Year of Record-Breaking Growth
The year 2024 proved to be a landmark year for the artificial intelligence (AI) sector, both in the United States and globally. A notable 49 startups achieved the remarkable milestone of securing funding rounds of $100 million or more. Among these, three companies successfully garnered multiple major rounds of funding, while an impressive seven managed to raise rounds exceeding $1 billion.
As we approach the end of 2025, it’s essential to reflect on how this year has fared in comparison. Remarkably, 2025 has already equaled 2024 in the number of companies that have raised $100 million or larger funding rounds. Furthermore, there’s a notable uptick in the number of companies that have secured multiple rounds of funding above this threshold in 2025 compared to the previous year.
Notable Funding Rounds in November 2025
Anysphere
In what has been described as a groundbreaking funding achievement, Anysphere, known for its viral vibe-coding platform, Cursor, raised an astounding $2.3 billion in a recent funding round. This round, announced on November 13, brings Anysphere’s valuation to $29.3 billion and marks its second fundraising event this year.
Parallel
On November 12, Parallel, an innovator in web infrastructure for AI agents, announced a successful $100 million Series A round. The funding, co-led by Index Ventures and Kleiner Perkins, signals strong investor confidence in their business model.
Hippocratic AI
Healthcare-focused startup Hippocratic AI raised $126 million in its Series C round, announced on November 3, pushing its valuation to $3.5 billion. This round, led by Avenir Growth, is notable as it is the company’s second funding event of 2025.
Highlights from October 2025
Fireworks AI
On October 28, Fireworks AI, which specializes in helping users create AI applications from open-source models, announced a $250 million Series C round. This funding values the company at $4 billion.
Uniphore
In another impressive milestone, Uniphore, an enterprise AI startup, raised $260 million in Series F funding on October 22, reaching a valuation of $2.5 billion. This round attracted notable investors, including Snowflake Ventures and Nvidia.
Sesame
Sesame, which operates in the voice AI space, secured $250 million in a Series B round announced on October 21, co-led by Sequoia and Spark Capital.
Key Funding Events in September 2025
Periodic Labs
On September 30, Periodic Labs announced a $300 million seed round aimed at developing an AI scientist. The round was led by Felicis and Andreessen Horowitz, with participation from Nvidia.
Cerebras Systems
Cerebras Systems, known for its AI infrastructure, celebrated a major achievement by raising $1.1 billion in its Series G round, valuing the company at $8.1 billion. This announcement came on September 30 and was co-led by Fidelity.
Upscale AI
Announced on September 17, Upscale AI garnered $100 million in a seed round, co-led by Maverick Silicon and Mayfield. This funding sets the company on a promising path in the competitive AI infrastructure landscape.
A Look Ahead
As we transition to 2026, industry analysts and investors are closely watching these developments in the AI sector. Given the momentum established over the last two years, it is likely that 2026 will continue this trend of robust investment and innovation. The successful fundraising by companies like Anysphere and Fireworks AI indicates a growing confidence and interest in AI solutions across various sectors, including healthcare, enterprise solutions, and infrastructure.
Conclusion
In conclusion, the AI industry’s growth trajectory remains formidable as we move toward 2026. The significant number of funding rounds exceeding $100 million in 2025 not only reflects investor confidence but also highlights the increasing importance of AI technologies in various industries. With robust funding, startups like Anysphere, Parallel, and Hippocratic AI are poised to drive the next wave of innovation, setting the stage for an exciting future in artificial intelligence. As stakeholders, including investors, consumers, and entrepreneurs, we should look forward to how these advancements will reshape industries and daily lives in the years to come.
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